Journal article

Childhood measles contributes to post-bronchodilator airflow obstruction in middle-aged adults: A cohort study

JL Perret, MC Matheson, LC Gurrin, DP Johns, JA Burgess, BR Thompson, AJ Lowe, J Markos, SS Morrison, CF McDonald, R Wood-Baker, C Svanes, PS Thomas, JL Hopper, GG Giles, MJ Abramson, EH Walters, SC Dharmage

Respirology | WILEY | Published : 2018

Abstract

Background and objective: Chronic obstructive pulmonary disease (COPD) has potential origins in childhood but an association between childhood measles and post-bronchodilator (BD) airflow obstruction (AO) has not yet been shown. We investigated whether childhood measles contributed to post-BD AO through interactions with asthma and/or smoking in a non-immunized middle-aged population. Methods: The population-based Tasmanian Longitudinal Health Study (TAHS) cohort born in 1961 (n = 8583) underwent spirometry in 1968 before immunization was introduced. A history of childhood measles infection was obtained from school medical records. During the fifth decade follow-up (n = 5729 responses), a su..

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Grants

Awarded by GlaxoSmithKline


Funding Acknowledgements

We acknowledge the TAHS participants and previous investigators, Drs Heather Gibson, Bryan Gandevia, Harold Silverstone and Norelle Lickiss. We thank Professor Mark Jenkins (Centre for Epidemiology and Biostatistics, Victoria) and Dr Iain Feather (Gold Coast Hospital, Queensland), who are TAHS investigators but not co-authors of this manuscript, for their assistance with obtaining funds and data collection. We also acknowledge all the study site co-ordinators and respiratory scientists who collected data in the lung function laboratories of Tasmania, Victoria, Queensland and New South Wales; the research interviewers and data entry operators; and the organizational roles of Ms Cathryn Wharton and Dr Desiree Meszaros. Furthermore, we thank the late Dr Jeff Pretto for converting our gas transfer factor and lung volume data to z-scores, and Professor Philip Quanjer from the Global Lung Function Initiative for converting the spirometric data. The Archives Office of Tasmania provided data from the 1968 and 1974 TAHS questionnaires and copies of the school medical records. J.L.P. was supported by Lung Foundation Australia (LFA). This study was supported by the National Health and Medical Research Council (NHMRC) of Australia, research grant 299901; the University of Melbourne; Clifford Craig Foundation; the Victorian, Queensland and Tasmanian Asthma Foundations; Royal Hobart Hospital; Helen MacPherson Smith Trust; GlaxoSmithKline; and John L. Hopper. The funding agencies had no direct role in the conduct of the study; the collection, management, statistical analysis and interpretation of the data; and preparation or approval of the manuscript.